Cell biochemistry and function and the integration of biomedical research (location, location, location)
نویسندگان
چکیده
منابع مشابه
Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function
T cell migration is crucial for an effective adaptive immune response to invading pathogens. Naive and memory T cells encounter pathogen antigens, become activated, and differentiate into effector cells in secondary lymphoid tissues, and then migrate to the site(s) of infection where they exert effector activities that control and eliminate pathogens. To achieve activation, efficient effector f...
متن کاملObesity and asthma: location, location, location.
T here is a worldwide epidemic of obesity. In the USA, the prevalence of obesity, defined as a body mass index (BMI) o30 kg?m, has increased among adults aged 20– 74 yrs from ,15% in the late 1970s to ,35% in 2010. Another third of the population is overweight (BMI o25 to ,30 kg?m). The obesity epidemic has impacted both developed and developing nations throughout the world. The World Health Or...
متن کاملLocation, location, location...
Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
متن کاملThe business of deubiquitination - location, location, location.
A majority of proteins in the cell can be modified by ubiquitination, thereby altering their function or stability. This ubiquitination is controlled by both ubiquitinating and deubiquitinating enzymes (DUBs). The number of ubiquitin ligases exceeds that of DUBs by about eightfold, indicating that DUBs may have much broader substrate specificity. Despite this, DUBs have been shown to have quite...
متن کاملLocation, location, location
Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
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ژورنال
عنوان ژورنال: Cell Biochemistry and Function
سال: 2009
ISSN: 0263-6484,1099-0844
DOI: 10.1002/cbf.1535